Protein Details: Glutamate receptor 2
Protein ID
ICDB_Pro_0812
Protein Name
Glutamate receptor 2
Gene Name
glr-2; B0280.12/K04G7.2
Organism
Caenorhabditis elegans
Length
977 amino acids
AlphaFoldDB
AF-Q10914-F1-model_v4.pdb
Function
L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. Required for response to mechanical and osmotic stimuli.
Sequence
MNKNLLVFGFLIFVKIGETSKKFPLRAFVASTDIDNDTAHAIIEMLRLAEMTFNALSDVDFDVLLGTRDLPPMEMATMMWNLNRIICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLIDWEPSKSENIGKTTENNPMIFSVAPSAEQLLIDYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSPKYQLFVDNYVAPSDEEMFKEFLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRALEESVLVKKEYHYVFSNFDVDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYRGGFSNTDSIPTAAAFAHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGRKGLYCRPHEDQTESRQFETFEHGKKIAEAIKKVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGVNSLNSIWERFQWAEGEGFLLGGERYVQEKKKDSSQTRKGILPSKPWQLRFNVVTVLVKPFVMLKRRNPGEPELKGNDRFEGYCIDLLNLLAKNITGFEYDVFISDGNKYGSRQADGSWDGMIGYLLNETADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGVSLTIFLVSWFSPYEKRIEFKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTANLAAFLTLERMTPPIESVEDLANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYADGIEKVRTSKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKGELKKLENKWWYDRGQCDTGTSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLFRKNKENREKERNRMRSSRPLKPGILASCERAKQKQLQNRRTKSEEVSTPRSTLF
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Command interneurons of the locomotory control circuit (AIA; AIB; AVA; AVD; AVE; PVC; RIA; RIG and RIR) and motor neurons (AVG; M1; RMDD and RMDV)
DOI ID
10.1016/s0896-6273(02)01088-7; 10.1126/science.282.5396.2012; 10.1523/jneurosci.21-05-01510.2001; 10.1074/mcp.m600392-mcp200
RefSeq
NP_001021113.1 [Q10914-2]; NP_001021114.1 [Q10914-1]